Below are some of our publicly available tools and cohort details that may be useful for both internal and collaborative research efforts.
H-GCTA (Hybrid Genome-wide Complex Trait Analysis) is a toolkit for analyzing heritability and genetic architecture of complex traits. Building on methods like GCTA, it introduces novel features to dissect maternal and fetal genetic contributions, making it especially suitable for studying pregnancy outcomes.
The FIN (Helsinki) birth cohort was collected for a genetic study of spontaneous preterm birth. It includes more than 1,600 mother–child pairs from Helsinki University Hospitals between 2004 and 2014, with all participants of Finnish descent. Gestational age was determined by crown-rump length at the first ultrasound screening (10–13 weeks). In total, 2,962 blood samples from mothers and children were genotyped, and after quality control and phenotype-based inclusion criteria, genotype data was available in 1,170 mother–child pairs.
BloodCellDecon is an R package for robust cell-type deconvolution of peripheral blood gene expression data. It estimates the proportions of major immune cell types from bulk RNA-seq or microarray data, helping researchers account for immune cell composition when studying complex diseases or pregnancy-related traits.