Advancing Maternal–Fetal Health Through Genomics
Welcome to the Pregnancy Genomics Lab, where we harness advanced genomic, epigenomic, and multi-omics techniques to investigate the intricate biological factors underlying pregnancy outcomes. Our work spans maternal and fetal genetics, dissecting how these intertwined contributions shape gestational duration, birth weight, and long-term health.
Our Approach
We employ an integrated multi-level analysis strategy in mother–child pairs, enabling us to distinguish maternal genetic influences from direct fetal genetic effects. At the first level, we identify individual loci and variants linked to pregnancy traits. Next, we consider cumulative polygenic effects to capture a broader spectrum of genetic risk and resilience. Finally, we investigate how these variants interact with each other and environmental exposures, revealing a comprehensive landscape of the genetic architecture behind pregnancy outcomes. Learn more about our Approach.
Key Research Areas
- Integrating Genomic Studies of Gestational Duration & Birth Weight: Jointly modeling these traits to reveal shared loci and maternal/fetal effects.
- Genomics & Multi-Omics in LMICs: Investigating global disparities in maternal–fetal health by leveraging large, diverse cohorts and cutting-edge technologies.
- Epigenomics of Pregnancy Outcomes: Examining how DNA methylation and other epigenetic marks mediate gene–environment interactions in mothers and infants.
- Functional Studies of Genes & Variants: Using CRISPR, animal models, and multi-omics assays to explore the biological mechanisms behind identified pregnancy-related loci.
Visit our Research page for more details on these and other ongoing projects.
Get Involved
Whether you’re a fellow researcher, clinician, or student, we welcome collaboration to advance maternal–infant health. Explore our Resources or contact us for any questions. Together, we can deepen our understanding of pregnancy genomics and translate these discoveries into real-world clinical benefits.